| Date | Team | Transaction |
| 08/18/2008 | | IF Matt Tolbert joins Rock Cats on major league rehab assignment. OF Danny Berg promoted from Ft. Myers (high-A). |
| 08/14/2008 | | OF Joe Gaetti placed on disabled list (torn Achilles tendon). |
| 08/12/2008 | | OF Joe Gaetti acquired from Oakland (AAA). |
| 08/09/2008 | | 1B Brock Peterson promoted to Rochester (AAA). CF Brandon Roberts acquired from Ft. Myers (high-A). |
| 08/06/2008 | | 1B/OF Erik Lis placed on disabled list (dislocated left shoulder). |
| 08/05/2008 | | LHP Jose Mijares promoted from Fort Myers (high A). |
| 08/01/2008 | | 2B Brian Dinkelman activated off disabled list. |
| 07/31/2008 | | IF/OF Luke Hughes promoted to Rochester (AAA). |
| 07/28/2008 | | RHP Anthony Swarzak promoted to Rochester (AAA). |
| 07/24/2008 | | IF Steve Tolleson activated from disabled list. |
| 07/23/2008 | | 2B Brian Dinkelman (elbow) placed on disabled list. |
| 07/04/2008 | | RHP Jay Rainville promoted from high A Ft. Myers. IF Steve Tolleson (finger) placed on DL retroactive to June 30. |
| 06/26/2008 | | IF/OF Luke Hughes reactivated from disabled list. |
| 06/16/2008 | | RHP Jeff Manship, RHP Rob Delaney, 3B Danny Valencia and 2B Brian Dinkelman promoted from Ft. Myers (A). RHP Oswaldo Sosa and RHP Jay Rainville reassigned to Ft. Myers (A). |
| 06/12/2008 | | RHP Frank Mata acquired from Ft. Myers (A). |
| 06/12/2008 | | IF Trevor Plouffe, C Jeff Christy promoted to Rochester (AAA). C Rodolfo Palacios acquired from Ft Myers (A). |
| 06/11/2008 | | LHP Errol Simonitsch released. |
| 06/10/2008 | | RHP Yohan Pino activated from disabled list. |
| 06/09/2008 | | IF/OF Luke Hughes (left groin strain) placed on disabled list. |
| 06/03/2008 | | IF Felix Molina returned from Rochester (AAA). |
| 05/23/2008 | | IF Felix Molina promoted to Rochester (AAA). |
| 05/16/2008 | | RHP Yohan Pino placed on seven-day disabled list (shoulder). |
| 05/12/2008 | | LHP Errol Simonitsch acquired from high Class A Fort Myers. |
| 05/09/2008 | | RHP Danny Graves promoted to Rochester |
| 05/08/2008 | | CF Brandon Roberts (leg) and RHP David Shinskie (shoulder) assigned to extended spring training in Ft. Myers. |
| 05/08/2008 | | LHP Errol Simonitsch activated off Rock Cats' disabled list and assigned to high Class A Fort Myers. |
| 04/28/2008 | | CF Brandon Roberts placed on 7-day disabled list |
| 04/28/2008 | | IF Toby Gardenhire promoted from Class A Fort Myers. |
| 04/22/2008 | | RHP Danny Graves obtained from Fort Myers (high A). |
| 04/21/2008 | | RHP David Shinskie placed on Disabled List (tendinitis). |